The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Nancy Hogg : Leukocyte Adhesion
The Leukocyte Adhesion laboratory investigated how immune cells move around the body and into internal tissues.
Leukocytes are motile cells which circulate in the blood stream until responding to tissue signals. By binding to ICAM-1, the integrin LFA-1(αLβ2;CD11a/CD18) mediates many adhesive interactions necessary for the function of leukocytes. Integrins on leukocytes are normally in an inactive state, preventing random interactions, and are activated via triggering through other receptors. The lab was interested in the signalling that leads to active LFA-1 as well as the signals generated by LFA-1 itself when it has bound ligand ICAM-1. A latter focus was on kindlin-3 which is mutated in LAD-III patients. The lab was also interested in how LFA-1 functions in vivo in lymph nodes and other tissues and for these studies we made use of an LFA-1-/- model.
Nancy closed her lab at the Lincoln's Inn Fields Laboratories at LRI in 2011, but remains an Emeritus Group Leader. (email: nancy.hogg@cancer.org.uk)
Selected Papers
Hobbs JA, May R, Tanousis K, McNeill E, Mathies M, Gebhardt C, Henderson R, Robinson MJ, Hogg N. Myeloid cell function in MRP-14 (S100A9) null mice. Mol Cell Biol. 2003;23:2564-2576
(Abstract)
McDowall A, Imwald D, Leitinger B, Klein N, Jones A, Liesner R, Hogg N. A novel form of integrin dysfunction involving β1, β2 and β3 integrins. J Clin Invest. 2003;111:51-60
(Abstract)
Smith A, Bracke M, Leitinger B, Porter J, Hogg N. LFA-1 induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J Cell Science. 2003;116:3123-3133
(Abstract)
Porter JC, Bracke M, Smith A, Davies D, Hogg N. Signalling through integrin LFA-1 leads to F actin remodelling, and enhanced cell adhesion. J Immunol. 2002;168:6330-6335
(Abstract)
Henderson R, Lim LHK, Tessier PA, Gavins F, Mathies M, Perretti M, Hogg N. The use of LFA-1 deficient mice to determine the role of LFA-1, Mac-1 and 4 integrin in the inflammatory response of neutrophils. J Exp Med. 2001;194:219-226
(Abstract)
Nancy Hogg