The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Ian Tomlinson
The lab’s work comprised three main strands, genetic susceptibility to cancer, functional genetics of colorectal tumorigenesis, and mitochondrial tumour susceptibility genes.
The aims of the Molecular and Population Genetics Laboratory:
- To identify cancer predisposition genes.
- To identify genetic changes that predict response to cancer therapy or indicate prognosis.
- To work out molecular pathways of tumorigenesis.
- To use genetic methods to elucidate the functional effects of mutations in tumour growth.
- To set up model systems for the analysis of tumorigenesis.
- To produce information that is clinically relevant.
Ian left the LRI to join the University of Oxford.
Significant LRI Papers
- Jaeger E, Webb E, Howarth K, Carvajal-Carmona L, Rowan A, Broderick P, Walther A, Spain S, Pittman A, Kemp Z, Sullivan K, Heinimann K, Lubbe S, Domingo E, Barclay E, Martin L, Gorman M, Chandler I, Vijayakrishnan J, Wood W, Papaemmanuil E, Penegar S, Qureshi M, Farrington S, Tenesa A, Cazier JB, Kerr D, Gray R, Peto J, Dunlop M, Campbell H, Thomas H, Houlston R, Tomlinson I. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat Genet. 2008;40:26-8 (Abstract)
- Sieber OM, Tomlinson SR, Tomlinson IPM. Tissue, cell and stage specificity of (epi)mutations in cancers. Nat Rev Cancer. 2005;5:649-55 (Abstract)
- Gottlieb E, Tomlinson IPM. Mitochondrial tumour suppressors: a genetic and biochemical update. Nat Rev Cancer. 2005;5:857-66 (Abstract)
- Sieber OM, Heinimann K, Tomlinson IPM. Genomic instability--the engine of tumorigenesis? Nat Rev Cancer. 2003;3:701-8 (Abstract)
- Tomlinson IPM, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomaki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen L A. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406-10 (Abstract)
