The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Doreen Cantrell : Lymphocyte Activation
The work of the Lymphocyte Activation Laboratory, headed by Doreen Cantrell, characterized the biochemical processes that integrate signals from antigen receptor and cytokine receptors and regulate lymphocyte function.
The principal upon which the lab's work was based was that T lymphocytes are an important physiological system for exploring the regulation and function of signal transduction pathways. The underlying goal of their work was to understand the signal transduction pathways that control T cell function and to use that information to develop strategies to manipulate the immune response.
Doreen is now a Professor of Cellular Immunology, Wellcome Trust Principal Research Fellow and Vice Principal and Head of the College of Life Sciences at Dundee University
Significant LRI Papers
- Costello PS, Gallagher M, Cantrell DA. Sustained and dynamic inositol lipid metabolism inside and outside the the immunological synapse. Nature Immunology. 2002;3:1082-1089 (Abstract)
- Sebzda E, Bracke M, Tugal T, Hogg N, Cantrell DA. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signalling. Nature Immunology. 2002;277:20104-20112 (Abstract)
- Costello PS, Cleverley SC, Galandrini R, Henning SW, Cantrell DA. The GTPase Rho controls a p53-dependent survival checkpoint during thymopoiesis. Journal of Experimental Medicine 2000;192:77-85 (Abstract)
- Gomez M, Tybulewicz V, Cantrell DA. Control of pre-T cell proliferation and differentiation by the GTPase Rac-1. Nature Immunology 2000;1:348- 352 (Abstract)
- Acuto O, Cantrell D. T cells activation and the cytoskeleton. Annual Review of Immunology 2000;18:165-184 (Abstract)