Selected Publications
Sancho, D., O. Joffre, A. Keller, N.C. Rogers, D. Martinez, P. Hernanz-Falcón, I. Rosewell, and C. Reis e Sousa. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009 458:899-903. PubMed
LeibundGut-Landmann, S., O. Groß, M. Robinson, F. Osorio, E. Slack, S. Tsoni, E. Schweighoffer, V. Tybulewicz, G. Brown, J. Ruland, and C. Reis e Sousa. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007 8:630-638. PubMed
Pichlmair, A., O. Schulz, C. Tan, T. Näslund, P. Liljeström, F. Weber, and C. Reis e Sousa. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 2006 314:997-1001. PubMed
Rogers N, Slack E, Edwards A, Nolte M, Schulz O, Schweighoffer E, Williams D, Gordon S, Tybulewicz V, Brown G and Reis e Sousa C. Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C-type lectins. Immunity 2005; 22: 507-517. PubMed
Schulz O, Diebold SS, Chen M, Näslund TI, Nolte MA, Alexopoulou L, Azuma Y-T, Flavell RA, Liljeström P and Reis e Sousa C. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 2005; 433: 887-892. PubMed
Spörri R and Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nature Immunol 2005; 6: 163-170. PubMed
Diebold SS, Kaisho T, Hemmi H, Akira S and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529-1531. PubMed
Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, Haswell LE, Al-Shamkhani A, Flavel R, Borrow P and Reis e Sousa C. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 2003; 424: 324-328. PubMed
Schulz, O., A. Edwards, M. Schito, J. Aliberti, S. Manickasingham, A. Sher, and C. Reis e Sousa. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 2000 13:453-462. PubMed
Primary Research Publications
2010
Poulin LF, Salio M, Griessinger E, Anjos-Afonso F, Craciun L, Chen JL, Keller AM, Joffre O, Zelenay S, Nye E, Le Moine A, Faure F, Donckier V, Sancho D, Cerundolo V, Bonnet D, Reis e Sousa C. Characterization of human DNGR-1(+) BDCA3(+) leukocytes as putative equivalents of mouse CD8 alpha(+) dendritic cells. J Exp Med 2010; 207 (6):1261-1271. UKPubMed (open access); PubMed; DOI: 10.1084/jem.20092618.
Joffre OP, Sancho D, Zelenay S, Keller AM, Reis e Sousa C. Efficient and versatile manipulation of the peripheral CD4(+) T-cell compartment by antigen targeting to DNGR-1/CLEC9A. Eur J Immunol 2010; 40 (5):1255-1265. PubMed; DOI: 10.1002/eji.201040419.
Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, Takeuchi O, Akira S, Kaufman RJ, Reis e Sousa C. Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity. Cell Host Microbe 2010; 7 (5):354-361. PubMed; DOI: 10.1016/j.chom.2010.04.007.
Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb N, Vreede F, Barclay W, Fodor E, Reis e Sousa C. RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection. Cell 2010; 140 (3):397-408. PubMed; DOI: 10.1016/j.cell.2010.01.020.
Rehwinkel J, Reis e Sousa C. RIGorous Detection: Exposing Virus Through RNA Sensing. Science 2010; 327 (5963):284-286. PubMed; DOI: 10.1126/science.1185068.
2009
Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, Reis e Sousa C. Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection. J Virol 2009; 83 (20):10761-10769. UKPubMed (open access); PubMed; DOI: 10.1128/JVI.00770-09.
Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, SjefVerbeek J, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med 2009; 206 (9):2037-2051. UKPubMed (open access); PubMed; DOI: 10.1084/jem.20082818.
Sancho D, Joffre OP, Keller AM, Rogers NC, Martinez D, Hernanz-Falcon P, Rosewell I, Reis e Sousa C. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009; 458 (7240):899-903. UKPubMed (open access); PubMed; DOI: 10.1038/nature07750.
Kerrigan AM, Dennehy KM, Mourao-Sa D, Faro-Trindade I, Willment JA, Taylor PR, Eble JA, Reis e Sousa C, Brown GD. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 2009; 182 (7):4150-4157. UKPubMed (open access); PubMed; DOI: 10.4049/jimmunol.0802808.
Diebold SS, Schulz O, Alexopoulou L, Leitner WW, Flavell RA, Reis e Sousa C. Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Ther 2009; 16 (3):359-366. UKPubMed (open access); PubMed; DOI: 10.1038/gt.2008.164.
Hernanz-Falcon P, Joffre O, Williams DL, Reis e Sousa C. Internalization of Dectin-1 terminates induction of inflammatory responses. Eur J Immunol 2009; 39 (2):507-513. UKPubMed (open access); PubMed; DOI: 10.1002/eji.200838687.
Joffre O, Nolte MA, Sporri R, Reis e Sousa C. Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol Rev 2009; 227 (1):234-247. PubMed; DOI: 10.1111/j.1600-065X.2008.00718.x.
2008
Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, Reis e Sousa C. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 2008; 38 (12):3274-3281. UKPubMed (open access); PubMed; DOI: 10.1002/eji.200838950.
LeibundGut-Landmann S, Osorio F, Brown GD, Reis e Sousa C. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood 2008; 112 (13):4971-4980. PubMed; DOI: 10.1182/blood-2008-05-158469.
Sancho D, Mourao-Sa D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest 2008; 118 (6):2098-2110. UKPubMed (open access); PubMed; DOI: 10.1172/JCI34584.
Worsley AGF, LeibundGut-Landmann S, Slack E, Phng LK, Gerhardt H, Reis e Sousa C, MacDonald AS. Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo. Eur J Immunol 2008; 38 (4):1043-1049. PubMed; DOI: 10.1002/eji.200737335.
2007
Pichlmair A, Reis e Sousa C. Innate recognition of viruses. Immunity 2007; 27 (3):370-383.
Slack EC, Robinson MJ, Hernanz-Falcon P, Brown GD, Williams DL, Schweighoffer E, Tybulewicz VL, Reis e Sousa C. Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. Eur J Immunol 2007; 37 (6):1600-1612.
Nolte MA, LeibundGut-Landmann S, Joffre O, Reis e Sousa C. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med 2007; 204 (6):1487-1501.
LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007; 8 (6):630-638.
Reis e Sousa C. Eating in to avoid infection. Science 2007; 315 (5817):1376-1377.
Pichlmair A, Diebold SS, Gschmeissner S, Takeuchi Y, Ikeda Y, Collins MK, Reis e Sousa C. Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. J Virol 2007; 81 (2):539-547. DOI: 10.1128/JVI.01818-06.
2006
Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur J Immunol 2006; 36 (12):3256-3267. DOI: 10.1002/eji.200636617.
Robinson MJ, Sancho D, Slack EC, LeibundGut-Landmann S, Reis e Sousa C. Myeloid C-type lectins in innate immunity. Nat Immunol 2006; 7 (12):1258-1265.
Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, Reis e Sousa C. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 2006; 314 (5801):997-1001.
Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006; 6 (6):476-483.
Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh C-S, Reis e Sousa C, Matsuura Y, Fujita T, Akira S. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441 (7089):101-105.
2005
Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005; 22 (4):507-517.
Schulz O, Diebold SS, Chen M, Naslund TI, Nolte MA, Alexopoulou L, Azuma Y-T, Flavell RA, Liljestrom P, Reis e Sousa C. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 2005; 433 (7028):887-892.
Sporri R, Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4(+) T cell populations lacking helper function. Nat Immunol 2005; 6 (2):163-170.
2004
Herre J, Marshall ASJ, Caron E, Edwards AD, Williams DL, Schweighoffer E, Tybulewicz V, Reis e Sousa C, Gordon S, Brown GD. Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 2004; 104 (13):4038-4045.
LeibundGut-Landmann S, Waldburger JM, Reis e Sousa C, Acha-Orbea H, Reith W. MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells. Nat Immunol 2004; 5 (9):899-908.
Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303 (5663):1529-1531.
Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 2004; 16 (1):27-34.
Reis e Sousa C. Activation of dendritic cells: translating innate into adaptive immunity. Curr Opin Immunol 2004; 16 (1):21-25.
2003
Sporri R, Reis e Sousa C. Newly activated T cells promote maturation of bystander dendritic cells but not IL-12 production. J Immunol 2003; 171 (12):6406-6413.
Edwards AD, Chaussabel D, Tomlinson S, Schulz O, Sher A, Reis e Sousa C. Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J Immunol 2003; 171 (1):47-60.
Reis e Sousa C, Diebold SS, Edwards AD, Rogers N, Schulz O, Sporri R. Regulation of dendritic cell function by microbial stimuli. Pathol Biol 2003; 51 (2):67-68.
Alberti J, Valenzuela JG, Carruthers VB, Hieny S, Andersen J, Charest H, Reis e Sousa C, Fairlamb A, Ribeiro JM, Sher A. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol 2003; 4 (5):485-490.
Edwards AD, Diebold SS, Slack EMC, Tomizawa H, Hemmi H, Kaisho T, Akira S, Reis e Sousa C. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha(+) DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol 2003; 33 (4):827-833.
Tsujimura H, Tamura T, Gongora C, Aliberti J, Reis e Sousa C, Sher A, Ozato K. ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Blood 2003; 101 (3):961-969. DOI: 10.1182/blood-2002-05-1327.
Manickasingham SR, Edwards AD, Schulz O, Reis e Sousa C. The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals. Eur J Immunol 2003; 33 (1):101-107.
Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A. Essential role for ICSBP in the in vivo development of murine CD8 alpha(+) dendritic cells. Blood 2003; 101 (1):305-310. DOI: 10.1182/blood-2002-04-1088.
Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, Haswell LE, Al-Shamkhani A, Flavell R, Borrow P, Reis e Sousa C. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 2003; 424 (6946):324-328.
2002
Sporri R, Reis e Sousa C. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8(+) T cells to foreign antigen. Eur J Immunol 2002; 32 (11):3161-3170.
Schulz O, Reis e Sousa C. Cross-presentation of cell-associated antigens by CD8 alpha(+) dendritic cells is attributable to their ability to internalize dead cells. Immunology 2002; 107 (2):183-189.
Edwards AD, Manickasingham SP, Sporri R, Diebold SS, Schulz O, Sher A, Kaisho T, Akira S, Reis e Sousa C. Microbial recognition via toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J Immunol 2002; 169 (7):3652-3660.
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M, Reis e Sousa C. CD36 or alpha v beta 3 and alpha v beta 5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha(+) murine dendritic cells. J Immunol 2002; 168 (12):6057-6065.
Aliberti J, Hieny S, Reis e Sousa C, Serhan CN, Sher A. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat Immunol 2002; 3 (1):76-82.
Other publications
Joffre O, Nolte MA, Spörri R, Reis e Sousa C. Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol Rev 2009; 227(1): 234-247.
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