Selected Publications
Mochida S and Hunt T. Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 2007; 449: 336-340. PubMed
Errico A, Costanzo V and Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci USA 2007; 104: 14929-14934. PubMed PDF (UKPMC)
Hochegger H, Dejsuphong D, Sonoda E, Saberi A, Rajendra E, Kirk J, Hunt T and Takeda S. An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol 2007; 178: 257-268. PubMed PDF (UKPMC)
Hunt T and Sassone-Corsi P. Riding tandem: circadian clocks and the cell cycle. Cell 2007; 129: 461-464. PubMed
Petri ET, Errico A, Escobedo L, Hunt T and Basavappa R. The Crystal Structure of Human Cyclin B. Cell Cycle 2007; 6: 1342-1349. PubMed
Primary Research Publications
2009
Hunt T. From concepts to cures-and back. EMBO Mol Med 2009; 1 (1):4-4. DOI: 10.1002/emmm.200900013.
Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V. Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion. EMBO J 2009; 28 (23):3681-3692. UKPubMed (open access); PubMed; DOI: 10.1038/emboj.2009.304.
Sigl R, Wandke C, Rauch V, Kirk J, Hunt T, Geley S. Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci 2009; 122 (22):4208-4217. PubMed; DOI: 10.1242/jcs.054197.
Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol 2009; 11 (11):1275-1276. PubMed; DOI: 10.1038/ncb1109-1275.
Mochida S, Ikeo S, Gannon J, Hunt T. Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J 2009; 28 (18):2777-2785. PubMed.
Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble MEM. The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc Natl Acad Sci U S A 2009; 106 (11):4171-4176. UKPubMed (open access); PubMed; DOI: 10.1073/pnas.0809674106.
2008
Kimata Y, Trickey M, Izawa D, Gannon J, Yamamoto M, Yamano H. A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Dev Cell 2008; 14 (3):446-454. PubMed.
Hunt T. You never know: Cdk inhibitors as anti-cancer drugs. Cell Cycle 2008; 7 (24):3789-3790. PubMed.
Ruiz EJ, Hunt T, Nebreda AR. Meiotic Inactivation of Xenopus Myt1 by CDK/XRINGO, but Not CDK/Cyclin, via Site-Specific Phosphorylation. Mol Cell 2008; 32 (2):210-220. PubMed.
Hochegger H, Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all?. Nat Rev Mol Cell Biol 2008; 9 (11):910-916. PubMed.
Trenz K, Errico A, Costanzo V. Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J 2008; 27 (6):876-885. UKPubMed (open access); PubMed; DOI: 10.1038/emboj.2008.29.
2007
Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R. The crystal structure of human cyclin B. Cell Cycle 2007; 6 (11):1342-1349.
Errico A, Costanzo V, Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A 2007; 104 (38):14929-14934.
Hunt T. European young investigators. Science 2007; 317 (5846):1833-1833.
Mochida S, Hunt T. Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 2007; 449 (7160):336-340.
Hochegger H, Deisuphong D, Sonoda E, Sciberi A, Rajendra E, Kirk J, Hunt T, Takeda S. An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol 2007; 178 (2):257-268.
Hunt T, Sassone-Corsi P. Riding tandem: Circadian clocks and the cell cycle. Cell 2007; 129 (3):461-464.
2005
Krupa A, Srinivasan N. Diversity in domain architectures of Ser/Thr kinases andtheir homologues in prokaryotes. BMC Genomics 2005; 6 :129.
Casaletto JB, Nutt LK, Wu QJ, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S. Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol 2005; 169 (1):61-71.
Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M, West SC. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005; 434 (7033):598-604.
Dinarina A, Perez LH, Davila A, Schwab M, Hunt T, Nebreda AR. Characterization of a new family of cyclin-dependent kinase activators. Biochem J 2005; 386 (Pt 2):349-355.
2004
Yamano H, Kominami K, Harrison C, Kitamura K, Katayama S, Dhut S, Hunt T, Toda T. Requirement of the SCFPop1/Pop2 ubiquitin ligase for degradation of the fission yeast S phase cyclin Cig2. J Biol Chem 2004; 279 (18):18974-18980.
Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, Lebendiker M, Brandeis M. Mammalian Cdh1/Fzr mediates its own degradation. EMBO J 2004; 23 (7):1619-1626.
Prigent C, Hunt T. Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Doree. Biol Cell 2004; 96 (3):181-185.
Yamano H, Gannon J, Mahbubani H, Hunt T. Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts. Mol Cell 2004; 13 (1):137-147.
2003
Sha W, Moore J, Chen K, Lassaletta AD, Yi CS, Tyson JJ, Sible JC. Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts. Proc Natl Acad Sci U S A 2003; 100 (3):975-980.
Moore JD, Kirk JA, Hunt T. Unmasking the S-phase-promoting potential of cyclin B1. Science 2003; 300 (5621):987-990.
Christopoulou L, Moore JD, Tyler-Smith C. Over-expression of wild-type Securin leads to aneuploidy in human cells. Cancer Lett 2003; 202 (2):213-218.
2002
Hunt T. Protein synthesis, proteolysis, and cell cycle transitions. Biosci Rep 2002; 22 (5-6):465-486.
Moore JD, Kornbluth S, Hunt T. Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. Mol Biol Cell 2002; 13 (12):4388-4400.
Graeser R, Gannon J, Poon RYC, Dubois T, Aitken A, Hunt T. Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. J Cell Sci 2002; 115 (17):3479-3490.
Doree M, Hunt T. From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?. J Cell Sci 2002; 115 (12):2461-2464.
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