Selected Publications
Bonnet D and Dick JE. Human acute leukemia is organized as a hierarchy, which originates from a primitive hematopoietic cell. Nature Medicine 1997; 3: 730-737. PubMed
Taussig DC, Oearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GH and Bonnet D. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005; 106: 4086-4092. PubMed Full text
Pearce DJ, Taussig D, Zibara K, Smith L-L, Ridler CM, Preudhomme C, Young BD, Rohatiner AZ, Lister TA and Bonnet D. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 2006; 107: 1166-1173. PubMed Full text
Rangatia J and Bonnet D. Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia 2006; 20: 68-76. PubMed
Kashofer K, Siapati EK and Bonnet D. In vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/ progenitor transplantation. Stem Cells 2006; 24: 1104-1112. PubMed
Primary Research Publications
2009
Aguilar S;Scotton CJ;McNulty K;Nye E;Stamp G;Laurent G;Bonnet D;Janes SM. Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-Induced Pulmonary Fibrosis. PLoS One 2009; 4 (11):e8013. UKPubMed (open access); PubMed; DOI: 10.1371/journal.pone.0008013.
Bonnet D. Humanized mouse models to study the human haematopoietic stem cell compartment. Methods Mol Biol 2009; 506 ():331-340. PubMed; DOI: 10.1007/978-1-59745-409-4_22.
Bonnet D. Humanized model to study leukemic stem cells. Methods Mol Biol 2009; 538 ():247-262. PubMed; DOI: 10.1007/978-1-59745-418-6_12.
Boxall SA;Cook GP;Pearce D;Bonnet D;El-Sherbiny YM;Blundell MP;Howe SJ;Leek JP;Markham AF;de Wynter EA. Haematopoietic repopulating activity in human cord blood CD133(+) quiescent cells. Bone Marrow Transplant 2009; 43 (8):627-635. PubMed; DOI: 10.1038/bmt.2008.368.
Oke A;Pearce D;Wilkinson RW;Crafter C;Odedra R;Cavenagh J;Fitzgibbon J;Lister AT;Joel S;Bonnet D. AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo. Cancer Res 2009; 69 (10):4150-4158. UKPubMed (open access); PubMed;.
Pearce D;Bonnet D. Ageing within the hematopoietic stem cell compartment. Mech Ageing Dev 2009; 130 (1-2 Spec Iss):54-57. PubMed; DOI: 10.1016/j.mad.2008.04.005.
2008
Bonnet D. In vivo evaluation of leukemic stem cells through the xenotransplantation model. Curr Protoc Stem Cell Biol 2008; 3 (2):1-3. PubMed;.
Anjos-Afonso F;Bonnet D. Isolation, culture, and differentiation potential of mouse marrow stromal cells. Curr Protoc Stem Cell Biol 2008; 2B (3):1-2B. PubMed;.
Virappane P;Gale R;Hills R;Kakkas I;Summers K;Stevens J;Allen C;Green C;Quentmeier H;Drexler H;Burnett A;Linch D;Bonnet D;Lister TA;Fitzgibbon J. Mutation of the Wilms' Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008; 26 (33):5429-5435. PubMed; DOI: 10.1200/JCO.2008.16.0333.
Taussig DC;Miraki-Moud F;Anjos-Afonso F;Pearce DJ;Allen K;Ridler C;Lillington D;Oakervee H;Cavenagh J;Agrawal SG;Lister TA;Gribben JG;Bonnet D. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood 2008; 112 (3):568-575. PubMed; DOI: 10.1182/blood-2007-10-118331.
Owen C;Virappane P;Alikian M;Stasevich I;Summers K;Lillington D;Bonnet D;Burnett A;Mills K;Lister TA;Fitzgibbon J. WTX is rarely mutated in acute myeloid leukemia. Haematologica 2008; 93 (6):947-948. PubMed;.
2007
Anjos-Afonso F;Bonnet D. Flexible and dynamic organization of bone marrow stromal compartment. Br J Haematol 2007; 139 (3):373-384.
Pearce DJ;Bonnet D. The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells. Exp Hematol 2007; 35 (9):1437-1446.
Aguilar S;Nye E;Chan J;Loebinger M;Spencer-Dene B;Fisk N;Stamp G;Bonnet D;Janes SM. Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells 2007; 25 (6):1586-1594.
Pearce DJ;Anjos-Afonso F;Ridler CM;Eddaoudi A;Bonnet D. Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging. Stem Cells 2007; 25 (4):828-835.
Siapati EK;Bigger BW;Kashofer K;Themis M;Thrasher AJ;Bonnet D. Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells. Eur J Haematol 2007; 78 (4):303-313.
Summers K;Stevens J;Kakkas I;Smith M;Smith LL;MacDougall F;Cavenagh J;Bonnet D;Young BD. Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML. Leukemia 2007; 21 (3):550-551.
Anjos-Afonso F;Bonnet D. Nonhematopoietic/endothelial SSEA-1(+) cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. Blood 2007; 109 (3):1298-1306. DOI: 10.1182/blood-2006-06-030551.
Ramasamy R;Lam EWF;Soeiro I;Tisato V;Bonnet D;Dazzi F. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 2007; 21 (2):304-310.
Pearce DJ;Bonnet D. Leukemia stem cells: studying the root of leukemia. Gene Ther Regul 2007; 3 (1):65-90. DOI: 10.1142/S1568558607000058.
2006
Kashofer K;Siapati EK;Bonnet D. In vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/progenitor transplantation. Stem Cells 2006; 24 (4):1104-1112. DOI: 10.1634/stemcells.2005-0405.
Pearce DJ;Taussig DC;Bonnet D. Implications of the expression of myeloid markers on normal and leukemic stem cells. Cell Cycle 2006; 5 (3):271-273.
Bigger BW;Siapati EK;Mistry A;Waddington SN;Nivsarkar MS;Jacobs L;Perrett R;Holder MV;Ridler C;Kemball-Cook G;Ali RR;Forbes SJ;Coutelle C;Wright N;Alison M;Thrasher AJ;Bonnet D;Themis M. Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther 2006; 13 (2):117-126. DOI: 10.1038/sj.gt.3302638.
Rangatia J;Bonnet D. Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia 2006; 20 (1):68-76. DOI: 10.1038/sj.leu.2403999.
Simpson C;Pearce DJ;Bonnet D;Davies D. Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources. J Immunol Methods 2006; 310 (1-2):171-181. DOI: 10.1016/j.jim.2006.01.005.
Smith L-L;Pearce D;Smith ML;Jenner M;Lister TA;Bonnet D;Goff L;Fitzgibbon J. Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia. Br J Haematol 2006; 133 (1):103-105.
Pearce DJ;Taussig D;Zilbara K;Smith L-L;Ridler CM;Preudhomme C;Young BD;Rohatiner AZ;Lister TA;Bonnet D. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 2006; 107 (3):1166-1173. UKPubMed (open access); DOI: 10.1182/blood-2005-06-2325.
2005
Bonnet D. Cancer stem cells: preface to the third issue of Stem Cell Reviews. Stem Cell Rev 2005; 1 (3):179-180.
Griffiths MJD;Bonnet D;Janes SM. Stem cells of the alveolar epithelium. Lancet 2005; 366 (9481):249-260.
Bonnet D. Leukemic stem cells show the way. Folia Histochem Cytobiol 2005; 43 (4):183-186.
Bonnet D. Cancer stem cells: AMLs show the way. Biochem Soc Trans 2005; 33 (6):1531-1533.
Danet-Desnoyers GH;Luongo JL;Bonnet DA;Domchek SM;Vonderheide RH. Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients. Exp Hematol 2005; 33 (11):1275-1280.
Bonnet D. Cancer stem cells: lessons from leukaemia. Cell Prolif 2005; 38 (6):357-361.
Siapati EK;Bigger BW;Miskin J;Chipchase D;Parsley KL;Mitrophanous K;Themis M;Thrasher AJ;Bonnet D. Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells. Mol Ther 2005; 12 (3):537-546.
Kashofer K;Bonnet D. Gene therapy progress and prospects: stem cell plasticity. Gene Ther 2005; 12 (16):1229-1234.
Bonnet D. Normal and leukaemic stem cells. Br J Haematol 2005; 130 (4):469-479.
Taussig DC;Pearce DJ;Simpson C;Rohatiner AZ;Lister TA;Kelly G;Luongo JL;Danet-Desnoyers GH;Bonnet D. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005; 106 (13):4086-4092. DOI: 10.1182/blood-2005-03-1072.
Pearce DJ;Taussig D;Simpson C;Allen K;Rohatiner AZ;Lister TA;Bonnet D. Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem Cells 2005; 23 (6):752-760.
Smith ML;Arch R;Smith L-L;Bainton N;Neat M;Taylor C;Bonnet D;Cavenagh JD;Lister TA;Fitzgibbon J. Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. Br J Haematol 2005; 128 (3):318-323.
Spencer H;Rampling D;Aurora P;Bonnet D;Hart SL;Jaffe A. Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation. Thorax 2005; 60 (1):60-62.
2004
Anjos-Afonso F;Siapati EK;Bonnet D. In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions. J Cell Sci 2004; 117 (23):5655-5664.
Pearce DJ;Ridler CM;Simpson C;Bonnet D. Multiparameter analysis of murine bone marrow side population cells. Blood 2004; 103 (7):2541-2546.
2003
Bonnet D. Hematopoietic stem cells. Birth Defects Res Part C Embryo Today 2003; 69 ():219-229.
Bonnet D. Biology of human bone marrow stem cells. Clin Exp Med 2003; 3 (3):140-149.
Danet GH;Pan Y;Luongo JL;Bonnet DA;Simon MC. Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest 2003; 112 (1):126-135.
2002
Danet GH;Luongo JL;Butler G;Lu MM;Tenner AJ;Simon MC;Bonnet DA. C1qR(p) defines a new human stem cell population with hernatopoietic and hepatic potential. Proc Natl Acad Sci U S A 2002; 99 (16):10441-10445.
Bonnet D. Haematopoietic stem cells. J Pathol 2002; 197 (4):430-440.
Taussig DC;Pearce DJ;Bonnet DA. Male cells in female recipients of hematopoietic-cell transplants. N Engl J Med 2002; 347 (3):219-219.
|
