The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Helle Ulrich : DNA Damage Tolerance
Goals
My lab is interested in understanding how post-translational protein modifications by members of the ubiquitin family, such as ubiquitin and SUMO, contribute to mutagenesis and the maintenance of genome stability, in particular in the context of lesion bypass during DNA replication.
Selected Papers
Saugar I, Parker JL, Zhao S, Ulrich HD. The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA. Nucleic Acids Res. 2012;40:245-57
(Abstract)
Parker JL, Ulrich HD. Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5. EMBO J. 2009;28:3657-3666
(Abstract)
Davies AA, Huttner D, Daigaku Y, Chen S, Ulrich HD. Activation of ubiquitin-dependent DNA damage bypass is mediated by Replication Protein A. Mol. Cell. 2008;29:625-636
(Abstract)
Sarkar S, Davies AA, Ulrich HD, McHugh PJ.DNA interstrand cross-link repair during G1 involves nucleotide excision repair and DNA polymerase z. EMBO J. 2006;25:1285-1294
(Abstract)
Papouli E, Chen S, Davies AA, Huttner D, Krejci L, Sung P, Ulrich HD. Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol. Cell. 2005;19(1):123-133
(Abstract)
Stelter P, Ulrich HD. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature. 2003;425(6954):188-191
(Abstract)
UlrichmHD, Jentsch S. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J. 2000;19(13): 3388-3397
(Abstract)
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Helle Ulrich
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