The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Gordon Peters : Molecular Oncology
Goals
We have a long-standing interest in the INK4a-ARF-INK4b tumour suppressor locus and its role in the implementation of senescence, the state of profound growth arrest that is elicited by various forms of cellular stress. In recent years, the emphasis of our research has shifted from the functions of the INK4a-ARF-INK4b gene products to the mechanisms that regulate their expression, and in particular the role of Polycomb group (PcG) proteins. PcG complexes are important for establishing the patterns of gene expression in each cell and are critical for the maintenance of pluripotency. They are also implicated in cancer, at least in part via suppression of INK4a-dependent senescence. Curiously, the INK4a locus is regulated by an extensive variety of PcG complexes and efforts to elucidate the underlying mechanisms have drawn us to genome-wide approaches in which we are considering fundamental aspects of PcG function.
Selected Papers
Gagrica S, Brookes S, Anderton E, Rowe J, Peters G. Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence. Cancer Res. 2012;72(1):165-175
(Abstract)
El Messaoudi-Aubert S, Nicholls J, Maertens GN, Brookes S, Bernstein E, Peters G. Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. Nat Struct Mol Biol. 2010;17(7):862-886
(Abstract)
Maertens GN, El Messaoudi-Aubert S, Elderkin S, Hiom K, Peters G. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010;29(15):2553-2565
(Abstract)
Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demtheylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009;23:1177-1182
(Abstract)
Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J, Rodriguez-Niedenführ M, Gil J, Peters G. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One. 2009;4:e6380
(Abstract)
Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol. 2006;7:667-677
(Abstract)
Kim SH, Rowe J, Fujii H, Jones R, Schmierer B, Kong BW, Kuchler K, Foster D, Ish-Horowicz D, Peters G. Upregulation of chicken p15INK4b at senescence and in the developing brain. J Cell Sci. 2006;119:2435-2443
(Abstract)
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Gordon Peters
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