Cancer Research UK

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The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.

Caetano Reis e Sousa : Immunobiology

Goals

Dendritic cells (DC) play a major role in the initiation and regulation of adaptive immune responses and, therefore, the manipulation of DC has tremendous potential for cancer immunotherapy and for vaccination against cancer-promoting infectious agents. The Immunobiology Laboratory at Cancer Research UK’s London Research Institute studies innate immune receptors and signalling pathways that trigger DC activation and promote T cell priming or that generally act to modulate the function of DC and other cells in response to changes in homeostasis. In a related research programme, the laboratory studies DC heterogeneity and ontogeny with a view to understand the role of distinct DC subtypes in mouse and in human

Selected Papers

Sancho D*, Joffre O*, Keller A, Rogers NC, Martinez D, Hernanz-Falcón P, Rosewell I, Reis e Sousa C. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature. 2009;458:899-903 (Abstract)
LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nature Immunol. 2007;8:630-638 (Abstract)
Pichlmair A, Schulz O, Tan CP, Näslund TI, Liljeström P, Weber F, Reis e Sousa C. RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5' Phosphates. Science. 2006;314: 997-1001 (Abstract)
Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C. Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C-type lectins. Immunity. 2005;22:507-517 (Abstract)
Schulz O, Diebold SS, Chen M, Näslund TI, Nolte M, Alexopoulou, L, Azuma Y-T, Flavell RA, Liljeström P, Reis e Sousa C. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature. 2005;433:887-892 (Abstract)

Papers

Further research papers

Projects

Current research areas

Team

Lab team members

Resources

Other lab information

Caetano Reis e Sousa

Tel +44 (0) 20 7269 2832
Fax
+44 (0) 20 7269 3479
Email

London Research Institute
Lincoln’s Inn Fields Laboratories
44 Lincoln’s Inn Fields
London
WC2A 3LY

Qualifications & History

1992 DPhil, University of Oxford, UK

1993 Visiting Fellow, National Institute of Allergy and Infectious Diseases, National Institute of Health, USA

1998 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)