Cancer Research UK

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The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.

Axel Behrens : Mammalian Genetics

Goals

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. The JNK family of mitogen activated protein kinases and the DNA damage kinase ATM (Ataxia Telangiectasia Mutated) are essential mediators of genome integrity and transcriptional control in eukaryotic cells. Our major focus is the elucidation of the molecular mechanism of JNK and ATM kinase signalling and to understand their function in stem cells and cancer.