The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Almut Schulze : Gene Expression Analysis
Goals
The overall aim of my research programme at the London Research Institute is to understand the contribution of metabolic processes in cancer development. We are interested in elucidating how cellular signalling pathways regulate cellular metabolic processes and how these processes contribute to cell growth, survival and stress resistance. Understanding the role of cell metabolism in cell transformation could lead to the identification of novel targets for drug development.
Selected Papers
Ferber E, Peck B, Delpeuch EO, Bell G, East P and Schulze A. (2011) FOXO3A regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death and Differentiation. 2012; 19(6):968-79.
(Abstract)
Jones NP, Schulze A. Targeting cancer metabolism - aiming at a tumour's sweet-spot. Drug Discov Today. 2012; 17(5-6):232-41.
(Abstract)
Ros S, Santos CR, Moço S, Baenke F, Kelly G, Howell M, Zamboni N and Schulze A. Functional screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB4) as an important regulator of prostate cancer cell survival. Cancer Discovery. 2012;2(4):328-43
(Abstract)
Schulze A, Downward J. Flicking the warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. Mol Cell. 2011;44(6):846-8.
(Abstract)
Porstmann T, Griffiths B, Santos C, Cully M, Wu M, Leevers S, Griffiths JR, Yuen-Li C, Schulze A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metabolism. 2009;8(3):224-236
(Abstract)
Porstmann, T, Santos CR, Lewis C, Griffiths B, Schulze A. A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochem Soc Trans. 2009;37(Pt 1):278-83
(Abstract)
Delpuech O, Griffiths B, East P, Essafi A, Lam EW, Burgering B, Downward J, Schulze A. Induction of Mxi1-SRalpha by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression. Mol Cell Biol. 2007;27(13):4917-30
(Abstract)
Porstmann T, Griffiths B, Chung Y-L, Delpuech O, Griffiths JR, Downward J, Schulze A. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene. 2005;24(43): 6465-81
(Abstract)
Schulze A, Lehmann K, Jefferies H, McMahon M and Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes and Development. 2001;15(8):981-994
(Abstract)
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Almut Schulze
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