The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Mark Petronczki : Cell Division and Aneuploidy
Publications
2012
Petronczki M, Uhlmann F. Cell biology. ESCRTing DNA at the cleavage site during cytokinesis. Science. 2012 Apr 13;336(6078):166-7.
(Abstract)
Petronczki M, Uhlmann F. ESCRTing DNA at the cleavage site during cytokinesis. Science 2012; 336(6078):166-7
(Abstract)
2011
Kerr GW, Sarkar S, Tibbles KL, Petronczki M, Millar JB, Arumugam P. Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk. Journal of Cell Biology. 2011;193(7):1157-66
(Abstract)
Su KC, Takaki T, Petronczki M. Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis. Developmental Cell. 2011 Dec 13;21(6):1104-15.
(Abstract)
2010
Lekomtsev S, Guizetti J, Pozniakovsky A, Gerlich DW, Petronczki M. Evidence that the tumor suppressor protein BRCA2 does not regulate cytokinesis in human cells. Journal of Cell Science. 2010;123:1395-1400
(Abstract)
Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M, Griffith JD, West SC. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nature Structural & Molecular Biology. 2010;17:241-3
(Abstract)
Vázquez-Novelle MD, Mirchenko L, Uhlmann F, Petronczki M. The 'anaphase problem': how to disable the mitotic checkpoint when sisters split Bioch. Soc. Trans. 2010;38(6):1660-6
(Abstract)
Vázquez-Novelle MD, Petronczki M. Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Current Biology. 2010;20(15):1402-7
(Abstract)
2009
Wolfe BA, Takaki T, Petronczki M, Glotzer M. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biology. 2009;7:e1000110
(Abstract)
2008
Petronczki M, Lenart P, Peters JM. Polo on the rise-from mitotic entry to cytokinesis with Plk1. Developmental Cell. 2008;14:646-59 (Co-corresponding author)
(Abstract)
Takaki T, Trenz K, Costanzo V, Petronczki M. Polo-like kinase 1 reaches beyond mitosis-cytokinesis, DNA damage response, and development. Current Opinion in Cell Biology. 2008;20:650-660. (Corresponding author)
(Abstract)
2007
Gregan J, Riedel CG, Petronczki M, Cipak L, Rumpf C, Poser I, Buchholz F, Mechtler K, Nasmyth K. Tandem affinity purification of functional TAP-tagged proteins from human cells. Nature Protocols. 2007;2:1145-1151
(Abstract)
Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Current Biology. 2007;17:304-315
(Abstract)
Petronczki M, Glotzer M, Kraut N, Peters JM. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Developmental Cell. 2007;12:713-725
(Abstract)
Steegmaier M, Hoffmann M, Baum A, Lénárt P, Petronczki M, Krssák M, Gürtler U, Garin-Chesa P, Lieb S, Quant J, Grauert M, Adolf GR, Kraut N, Peters JM, Rettig WJ. BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Current. Biology. 20007;17:316-322
(Abstract)
2006
Petronczki M, Matos J, Mori S, Gregan J, Bogdanova A, Schwickart M, Mechtler K, Shirahige K, Zachariae W, Nasmyth K. Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Cell. 2006;126:1049-1064
(Abstract)
Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K. Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature. 2006;441:53-61
(Abstract)
2004
Hutterer A, Betschinger J, Petronczki M, Knoblich JA. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Developmental Cell. 2004;6:845-854
(Abstract)
Petronczki M, Chwalla B, Siomos MF, Yokobayashi S, Helmhart W, Deutschbauer AM, Davis RW, Watanabe Y, Nasmyth K. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. Journal of Cell Science. 2004;117:3547-3559
(Abstract)
2003
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Tóth A, Nasmyth K. Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Developmental Cell. 2003;4:727-739
(Abstract)
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