Martin Singleton : Macromolecular Structure and Function

Publications

2012

Perriches T, Singleton MR. The structure of the yeast kinetochore Ndc10 DNA-binding domain reveals an unexpected evolutionary relationship to tyrosine recombinases. J Biol Chem. 2012;287(7):5173-5179 (Abstract)

Zhang G, Kelstrup CD, Hu XW, Hansen MJ, Singleton MR, Olsen JV, Nilsson J. The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores. J Cell Sci. 2012 Mar 27. [Epub ahead of print] (Abstract)

2011

Kingston IJ, Yung JS, Singleton MR. Biophysical Characterization of the Centromere-specific Nucleosome from Budding Yeast. J Biol Chem. 2011;286(5):4021-6 (Abstract)

2010

Amaro AC, Samora CP, Holtackers R, Wang E, Kingston IJ, Alonso M, Lampson M, Mcainsh AD, Meraldi P. Molecular control of kinetochore-microtubule dynamics and chromosome oscillations. Nat. Cell Biol. 2010;12(4):319-329 (Abstract)

Maskell DP, Hu XW, Singleton MR. Molecular architecture and assembly of the yeast kinetochore MIND complex. J Cell Biol. 2010;190(5):823-34 (Abstract)

Rass U, Compton SA, Matos J, Singleton MR, Ip SC, Blanco MG, Griffith JD, West SC. Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev. 2010;24(14):1559-69 (Abstract)

2008

Purvis A, Singleton MR. Insights into kinetochore-DNA interactions from the structure of Cep3∆. EMBO Reps. 2008;9:56-62 (Abstract)

2007

Singleton MR, Dillingham MS, Wigley DB. Structure and mechanism of helicases and nucleic acid translocases. Ann. Rev. Biochem. 2007;76:23-50 (Abstract)

2006

Seybert A, Singleton MR, Cook N, Hall DR, Wigley DB. Communication between subunits within an archaeal clamp-loader complex. EMBO J. 2006;25:2209-2218 (Abstract)

2004

Singleton MR, Dillingham MS, Gaudier M, Kowalczykowski SC, Wigley DB. Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks. Nature. 2004;432:187-193 (Abstract)

2003

Singleton MR, Morales R, Grainge I, Cook N, Isupov MN, Wigley DB. Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix. J. Mol. Biol. 2003;343:547-557 (Abstract)

Singleton MR, Wigley DB. Multiple roles for ATP hydrolysis in Nucleic acid modifying enzymes. EMBO J. 2003;22:4579-4583 (Abstract)

2002

Seybert A, Scott DJ, Scaife S, Singleton MR, Wigley DB. Biochemical characterization of the clamp/clamp loader proteins from the Euryarchaeon Archaeoglobus fulgidus. Nucl. Acid. Res. 2002;30:4329-4338 (Abstract)

Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB. Structure of the single-strand annealing domain of Human RAD52 protein. Proc. Natl. Acad. Sci. USA. 2002;99:13492-13497 (Abstract)

Singleton MR, Wigley DB. Specialisation and modularity in superfamily 1 and 2 helicases. J. Bacteriol. 2002;184:1819-1826 (Abstract)

2001

Singleton MR, Littlechild JA. Pyrrolidone carboxyl peptidase from Thermococcus litoralis. Meth. Enzym. 2001;330:394-403 (Abstract)

Singleton MR, Scaife S, Wigley DB. Structural analysis of DNA replication fork reversal by RecG. Cell. 2001;107:79-89 (Abstract)

Singleton MR. Scaife S, Raven ND, Wigley DB. Crystallisation and preliminary X-ray analysis of RecG, a replication-fork reversal helicase from Thermotoga Maritima complexed with a three-way DNA junction. Acta Cryst. 2001;D57:1695-1696 (Abstract)

2000

Singleton MR, Sawaya MR, Ellenberger T, Wigley DB. Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides. Cell. 2000;101:589-600 (Abstract)

Singleton MR, Taylor SJ, Parrat JS, Littlechild JA. Cloning, expression, and characterization of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis. Extremophiles. 2000;4(5):297-303 (Abstract)

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