The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Vincenzo Costanzo : DNA Damage and Genomic Stability
Publications
2012
Errico A, Costanzo V. Mechanisms of replication fork protection: a safeguard for genome stability. Crit Rev Biochem Mol Biol. 2012 Feb 11. [Epub ahead of print]
(Abstract)
Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M. RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell. 2012 Jan 13;45(1):99-110.
(Abstract)
Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen KJ, Fachinetti D, Bermejo R, Cocito A, Costanzo V, Lopes M. Topoisomerase I poisoning results in PARP-mediated replication fork reversal. Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2258. [Epub ahead of print]
(Abstract)
2011
Brca2, Rad51 and Mre11: performing balancing acts on replication forks. Costanzo V. DNA Repair (Amst). 2011;10(10):1060-5.
(Abstract)
Cosentino C, Grieco D, Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J. 2011;30(3):546-55
(Abstract)
Costanzo V. Brca2, Rad51 and Mre11: Performing balancing acts on replication forks. DNA Repair (Amst). 2011 Sep 5. [Epub ahead of print]
(Abstract)
Hashimoto Y, Puddu F, Costanzo V. RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol. 2011 Dec 4. doi: 10.1038/nsmb.2177. [Epub ahead of print]
(Abstract)
Studying DNA replication fork stability in Xenopus egg extract. Hashimoto Y, Costanzo V. Methods Mol Biol. 2011;745:437-45.
(Abstract)
2010
Balestrini A, Cosentino C, Errico A, Garner E and Costanzo V. GEMC1, is TopBP1 interacting protein is required for chromosomal DNA replication. Nat Cell Biol. 2010;12(5):484-91
(Abstract)
Errico A, Costanzo V. Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns. EMBO Rep. 2010;11(4):270-8
(Abstract)
Hashimoto Y, Chaudhuri AR, Lopes M, Costanzo V. Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol. 2010;17(11):1305-11
(Abstract)
Piergiovanni G, Costanzo V. GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication. Cell Cycle. 2010;9(18)3662-6
(Abstract)
2009
Brown N, Costanzo V. An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly. Cell Cycle. 2009;8(13):1997-2001 Review
(Abstract)
Costanzo V, Chaudhuri J, Fung JC, Moran JV. Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair. EMBO Rep. 2009;10(8):837-42. Review
(Abstract)
Costanzo V. A novel DNA damage checkpoint monitoring mitosis progression. Cell division. 2009; In press
(Abstract)
Costanzo V. Cep63, a novel player downstream ATM and ATR. Cell cycle. 2009; In press
(Abstract)
Errico A, Cosentino C, Rivera T, Losada A, Schwob E. Hunt T and Costanzo V. Tipin/Tim1/And1 protein complex promotes Pol α chromatin binding and sister chromatid cohesion. EMBO J. 2009;28(23):3681-92
(Abstract)
Garner E, Costanzo V. Studying the DNA damage response using in vitro model systems. DNA Repair (Amst). 2009;8(9):1025-37. Review
(Abstract)
Russo I, Cosentino C, Del Giudice E, Broccoletti T, Amorosi S, Cirillo E, Aloj G, Fusco A, Costanzo V, Pignata C. In ataxia-teleangiectasia betamethasone response is inversely correlated to cerebellar atrophy and directly to antioxidative capacity. Eur J Neurol. 2009;16(6):755-9
(Abstract)
Smith E, Costanzo V. Responding to chromosomal breakage during M-phase: insights from a cell-free system. Cell Division. 2009;4:15. Review
(Abstract)
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