The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Nick Wright : Histopathology
Publications
2012
Alison MR, Lin WR, Lee CY, Poulsom R, Wright NA, Otto WR. The Ailing Gut: A Therapeutic Role for Bone Marrow Cells? Transplantation. 2012 Jan 4. [Epub ahead of print]
(Abstract)
Amrania H, Antonacci G, Chan CH, Drummond L, Otto WR, Wright NA, Phillips C. Digistain: a digital staining instrument for histopathology. Opt Express. 2012 Mar 26;20(7):7290-9. doi: 10.1364/OE.20.007290.
(Abstract)
Guppy NJ, El-Bahrawy ME, Kocher HM, Fritsch K, Qureshi YA, Poulsom R, Jeffery RE, Wright NA, Otto WR, Alison MR. Trefoil Factor Family Peptides in Normal and Diseased Human Pancreas. Pancreas. 2012 Jan 26. [Epub ahead of print]
(Abstract)
Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol. 2012 Mar 4. doi: 10.1038/ncb2464. [Epub ahead of print]
(Abstract)
Wright NA. Stem cell identification - in vivo lineage analysis versus in vitro isolation and clonal expansion. J Pathol. 2012 Mar 9. doi: 10.1002/path.4018. [Epub ahead of print]
(Abstract)
2011
Gaisa NT, Graham TA, McDonald SA, Poulsom R, Heidenreich A, Jakse G, Knuechel R, Wright NA. Clonal architecture of human prostatic epithelium in benign and malignant conditions. J Pathol. 2011 Oct;225(2):172-80. doi: 10.1002/path.2959
(Abstract)
Galandiuk S, Rodriguez-Justo M, Jeffery R, Nicholson AM, Cheng Y, Oukrif D, Elia G, Leedham SJ, McDonald SA, Wright NA, Graham TA. Field Cancerization in Intestinal Epithelium of Patients with Crohn's Ileocolitis. Gastroenterology. 2011 Dec 13. [Epub ahead of print]
(Abstract)
Graham TA, McDonald SA, Wright NA. Field cancerization in the GI tract. Future Oncol. 2011;7(8):981-93
(Abstract)
Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, Leedham SJ, Novelli MR, Gay LJ, Ventayol-Garcia T, Green A, Mitchell I, Stoker DL, Preston SL, Bamba S, Yamada E, Kishi Y, Harrison R, Jankowski JA, Wright NA, McDonald SA. The clonal origins of dysplasia from intestinal metaplasia in the human stomach. Gastroenterology. 2011;140(4):1251-1260.e1-6
(Abstract)
Lee CY, Jeffery R, Hutchinson G, Alison MR, Poulsom R, Wright NA, Otto WR. Bone Marrow Cells in Murine Colitis: Multi-Signal Analysis Confirms Pericryptal Myofibroblast Engraftment without Epithelial Involvement. PLoS One. 2011;6(10):e26082
(Abstract)
March HN, Rust AG, Wright NA, Ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ, Adams DJ. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet. 2011 Nov 6;43(12):1202-9. doi: 10.1038/ng.990.
(Abstract)
Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R, Wright NA, McDonald SA, Jankowski JA. Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut. 2011 Dec 26. [Epub ahead of print]
(Abstract)
Wright NA, Poulsom R. Omnis cellula e cellula revisited: cell biology as the foundation of pathology. J Pathol. 2011 Oct 18. doi: 10.1002/path.3030
(Abstract)
Zeki SS, Graham TA, Wright NA. Stem cells and their implications for colorectal cancer. Nat Rev Gastroenterol Hepatol. 2011;8(2):90-100
(Abstract)
2010
Alferez DG, Ryan AJ, Goodlad RA, Wright NA, Wilkinson RW. Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model. Int J Oncol. 2010;37(4):767-72
(Abstract)
Ashrafian H, O’Flaherty L, Adam J, Steeples V, Chung Y-L, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell P, Stamp G, Poulsom R, Pugh C, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ. Fumarate Hydratase Deficiency Promotes An Oncogenic Metabolic Milieu Reminiscent of the Warburg Effect. Cancer Research 2010. OnlineFirst October 26, 2010;
(Abstract)
Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M,Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell. 2010;6(1):25-36
(Abstract)
Graham TA, Jawad N, Wright NA. Spindles losing their bearings: does disruption of orientation in stem cells predict the onset of cancer. Bioessays. 2010;32(6):468-72
(Abstract)
Graham TA, Leedham SJ. Field defects in DNA repair: is loss of MGMT an initial event in colorectal carcinogenesis? Gut. 2010;59(11):1452-3
(Abstract)
Graham TA, McDonald SAC. Genetic diversity during the development of Barrett's Oesophagus associated adenocarcinoma: how, when and why? Biochemical Society Transactions. 2010;38(2):374-379
(Abstract)
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