The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Stephen West : Genetic Recombination
Publications
2012
Blackford AN, Schwab RA, Nieminuszczy J, Deans AJ, West SC, Niedzwiedz W. The DNA translocase activity of FANCM protects stalled replication forks. Hum Mol Genet. 2012;21(9):2005-16
(Abstract)
2011
Deans A, West SC. DNA Interstrand crosslink repair and cancer. Nature Rev. Cancer. 2011;11:467-80
(Abstract)
Matos J, Blanco MG, Maslen SL, Skehel JM, West SC. Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell. 2011;147:158-172
(Abstract)
Wechsler T, Newman S, West SC. Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature. 2011;471:642-646
(Abstract)
2010
Blanco MG, Matos J, Rass U, Ip SC, West SC. Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA damage repair in S. cerevisiae. DNA Repair (Amst). 2010;9:394-402
(Abstract)
Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D. Solution structure of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat Struct Mol Biol. 2010;17:241-243
(Abstract)
Lorenz A, West SC, Whitby MC. The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant. Nucleic Acids Res. 2010;38:1866-1873
(Abstract)
MacKay C, Déclais AC, Lundin C, Agostinho A, Deans AJ, MacArtney TJ, Hofmann K, Gartner A, West SC, Helleday T, Lilley DM, Rouse J. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell. 2010;142:65-76
(Abstract)
Rass U, Compton SA, Matos J, Singleton MR, Ip SC, Blanco MG, Griffith JD, West SC. Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev. 2010;24:1559-1569
(Abstract)
Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M, Griffith JD, West SC. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat. Struct. Mol. Biol. 2010;17:1263-1265
(Abstract)
Wyatt HDM, West SC, and Beatie TL. InTERTpreting telomerase structure and function. Nucl. Acids Res. 2010;38:5609-5622
(Abstract)
Youds JL, Mets DG, McIlwraith MJ, Martin JS, Ward JD, ONeil NJ, Rose AM, West SC, Meyer BJ, Boulton SJ. RTEL-1 controls the crossover/non-crossover ratio to enforce meiotic crossover interference and homeostasis. Science. 2010;327:1254-1258
(Abstract)
2009
Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. Poly (ADP-ribose) dependent regulation of the chromatin remodelling enzyme ALC1 in response to DNA damage. Science. 2009;325:1240-1243
(Abstract)
Deans AJ, West SC. FANCM connects the genome instability disorders Bloom’s Syndrome and Fanconi Anemia. Mol. Cell. 2009;36:943-953
(Abstract)
Poulet A, Buisson R, Faivre-Moskalenko C, Koelblen M, Amiard S, Montel F, Cuesta-Lopez S, Bornet O, Guerlesquin F, Godet T, Moukhtar J, Argoul F, Déclais AC, Lilley DM, Ip SC, West SC, Gilson E, Giraud-Panis MJ. TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J. 2009;28:641-651
(Abstract)
West SC. The search for the human Holliday junction resolvase. Biochem. Soc. Trans. 2009;37:519-526
(Abstract)
2008
Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC. Poly(ADP-ribose)-binding zinc finger motif in DNA repair/checkpoint proteins. Nature. 2008;451:81-85
(Abstract)
Barber LJ, Youds JL, Ward JD, McIlwraith MJ, O'Neil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB, Auclair M, Tissenbaum H, West SC, Rose AM, Boulton SJ. RTEL maintanis genomic stability by suppressing homologous recombination. Cell. 2008;135:261-271
(Abstract)
Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ. FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell. 2008;32:313-324
(Abstract)
Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC. Identification of Holliday junction resolvases from humans and yeast. Nature. 2008;456:357-361
(Abstract)
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