The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Takashi Toda : Cell Regulation
Publications
2012
Okamoto SY, Sato M, Toda T, Yamamoto M. SCF Ensures Meiotic Chromosome Segregation Through a Resolution of Meiotic Recombination Intermediates. PLoS One. 2012;7(1):e30622. Epub 2012 Jan 23.
(Abstract)
2011
Hsu KS, Toda T. Ndc80 Internal Loop Interacts with Dis1/TOG to Ensure Proper Kinetochore-Spindle Attachment in Fission Yeast. Curr Biol. 2011;21(3):214-20
(Abstract)
Ikebe C, Konishi M, Hirata D, Matsusaka T, Toda T. Systematic Localization Study on Novel Proteins Encoded by Meiotically Up-Regulated ORFs in Fission Yeast. Biosci Biotechnol Biochem. 2011 Dec 7. [Epub ahead of print]
(Abstract)
Kume K, Koyano T, Kanai M, Toda T, Hirata D. Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth. Nat Cell Biol. 2011;13(3):234-42
(Abstract)
Masuda H, Fong CS, Ohtsuki C, Haraguchi T, Hiraoka Y. Spatiotemporal regulations of Wee1 at the G2/M transition. Mol Biol Cell 2011; 22 (5): 555-69
(Abstract)
2010
Fong CS, Sato M, Toda T. Fission yeast Pcp1 links polo kinase-mediated mitotic entry to γ-tubulin-dependent spindle formation. EMBO J. 2010;29(1):120-130
(Abstract)
Goshima T, Kume K, Koyano T, Ohya Y, Toda T, Hirata D. Fission yeast GC kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis. J Biol Chem. 2010;285(45):35196-205
(Abstract)
Koyano T, Kume K, Konishi M, Toda T, Hirata D. Search for Kinases Related to Transition of Growth Polarity in Fission Yeast. Biosci Biotechnol Biochem. 2010;74(5):1129-1133
(Abstract)
Sato M, Toda T. Space shuttling in the cell: Nucleocytoplasmic transport and microtubule organization during the cell cycle. Nucleus. 2010;1(3):231-236
(Abstract)
Takayama Y, Mamnun YM, Trickey M, Dhut S, Masuda F, Yamano H, Toda T, Saitoh S. Hsk1-and SCFPof3-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function. Dev Cell. 2010;18(3):385-396
(Abstract)
Takayama Y, Toda T. Coupling histone homeostasis to centromere integrity via the ubiquitin-proteasome system. Cell Div. 2010;5:18
(Abstract)
2009
Jourdain I, Spielewoy N, Thompson J, Dhut S, Yates JR, Toda T. Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Biochem. J. 2009;420:169-177
(Abstract)
Sato M, Okada N, Kakui Y, Yamamoto M, Yoshida M, Toda T. Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast. EMBO Rep. 2009;10:1161–1167
(Abstract)
Sato M, Toya M, Toda T. Visualization of fluorescence-tagged proteins in fission yeast and the analysis of mitotic spindle dynamics using GFP-tubulin under the native promoter. Methods in Mol Biol – Mitosis. 2009;545:185-203 ed. Andrew McAinsh. Humana Press Inc. NJ, USA.
(Abstract)
2008
Griffiths K, Masuda H, Dhut S, Toda T. Fission yeast dam1-A8 mutant is resistant to and rescued by an anti-microtubule agent. Biochem. Biophys. Res. Commun. 2008;368:670–676
(Abstract)
Sato M, Toya M, Toda T. Is spindle formation in fission yeast specific to the species?: from the viewpoint of nuclear transport and spindle pole body. [Article in Japanese] Tanpakushitsu Kakusan Koso. 2008;53:197-206
(Abstract)
Unsworth A, Masuda H, Dhut S, Toda T. Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics. Mol Biol Cell. 2008;19:5104-5115
(Abstract)
2007
Kearsey SE, Stevenson AL, Toda T, Wang SW. Fission yeast Cut8 is required for the repair of DNA double-strand breaks, rDNA maintenance and cell survival in the absence of Rqh1 helicase. Mol. Cell. Biol. 2007;27:1558-1567
(Abstract)
Kume K, Goshima T, Miyahara K, Toda T, Hirata D. A method for Pmo25-associated kinase assay in fission yeast: the activity is dependent on two GC kinases Nak1 and Sid1. Biosci. Biotechnol. Biochem. 2007;71:615-617
(Abstract)
Murakami H, Goto DB, Toda T, Chen ES, Grewal SI, Martienssen RA, Yanagida M. Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS ONE. 2007;27:e317
(Abstract)
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