The London Research Institute research groups are based at Lincoln’s Inn Fields and Clare Hall. Our major research themes are: the biology of tumours and tissues, cellular regulatory mechanisms and genomic integrity and cell cycle.
Takashi Toda : Cell Regulation
Goals
High-fidelity chromosome transmission lies at the heart of successive and successful cell division. One and only one mission of mitosis is, therefore, to ensure equal partition of sister chromatids to two daughter cells (or one mother and one daughter cell). Any errors in this process would lead to production of aneuploid progenies, a hallmark of many human cancers. Our laboratory has been working on the molecular mechanisms of how mitotic progression is organised and coordinated, particularly focusing on how bipolar spindle microtubules are assembled. We have been using the fission yeast as a model for a long time and recently started to study human cells to examine evolutionary conservations of the findings and their implications that we have obtained from yeast systems.
Selected Papers
Hsu KS, Toda T. Ndc80 Internal Loop Interacts with Dis1/TOG to Ensure Proper Kinetochore-Spindle Attachment in Fission Yeast. Curr Biol. 2011;21(3):214-20
(Abstract)
Kume K, Koyano T, Kanai M, Toda T, Hirata D. Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth. Nat Cell Biol. 2011;13(3):234-42
(Abstract)
Fong CS, Sato M, Toda T. Fission yeast Pcp1 links polo kinase-mediated mitotic entry to γ-tubulin-dependent spindle formation. EMBO J. 2010;29(1):120-130
(Abstract)
Takayama Y, Mamnun YM, Trickey M, Dhut S, Masuda F, Yamano H, Toda T, Saitoh S. Hsk1-and SCFPof3-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function. Dev Cell. 2010;18(3):385-396
(Abstract)
Sato M, Toda T. Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast. Nature. 2007;447:334-337
(Abstract)
Toya M, Sato M, Haselmann U, Asakawa K, Brunner D, Antony C, Toda T. γ-Tubulin complex-mediated anchoring of spindle microtubules to spindle-pole bodies requires Msd1 in fission yeast. Nat. Cell Biol. 207;9:646-653
(Abstract)
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Takashi Toda
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