Michael Way
The role of Rho GTPases in the regulation of cortical actin and its interaction with microtubules during cell migration
See Michael Way's research profile
Previous and current research
The spatial and temporal regulation of cell adhesion and motility is essential during development and throughout the lifetime of multicellular organisms. Consequently, defects in these two fundamental cell processes can be devastating, causing tumour cells to metastasise to distant parts of the body to establish new tumours. Understanding the molecular basis of signalling networks and their role in regulating the cell adhesion and migration represents a formidable task.
Work in the lab is aimed at unravelling this problem using a multidisciplinary approach that involves the latest imaging approaches, in a variety of systems, including vaccinia virus infected cells. The project, which is aimed at understanding the role of RhoGTPases in the regulation of virus induced cell motility, will examine how the interaction between microtubules and the actin cortex is regulated during cell migration.
References
Yoshiki A, et al. The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host and Microbe 2007; 1: 226-240.
Yoshiki A, et al. F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule dynamics during vaccinia infection. Cell Host and Microbe 2007; 1: 213-226.
Valderrama F, et al. Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signalling. Science 2006; 311: 377-381.
Newsome TP, et al. Src mediates a switch from microtubule- to actin-based motility of vaccinia virus. Science 2004; 306: 124-129.
A list of Michael Way's other publications can be found on his research profile.
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